Table 3.
Significant differences in gray matter density between marijuana users (MJ) and healthy controls (CON): whole-brain analysis
| Area | Region | Hemisphere | x | y | z | Peak z | Volume, mm3 |
|---|---|---|---|---|---|---|---|
| MJ > CON | |||||||
| Frontal | Middle frontal gyrus | R | 30 | −10 | 44 | 3.71 | 48 |
| Parietal | Precuneus | R | 24 | −60 | 26 | 4.16 | 472 |
| Postcentral gyrus | L | −24 | −36 | 58 | 3.75 | 184 | |
| Temporal | Insula | L | −30 | 14 | 2 | 3.63 | 80 |
| Subcortical | Nucleus accumbens/putamen | L | −12 | 2 | −10 | 4.19 | 296 |
| Amygdala | L | −24 | −12 | −8 | 3.56 | 40 | |
| Occipital | Lateral occipital cortex | R | 36 | −76 | 30 | 3.69 | 48 |
| Occipital cortex | L | −20 | −78 | 26 | 3.73 | 56 | |
| CON > MJ | |||||||
| Frontal | Frontal pole | R | 32 | 54 | 6 | 3.94 | 760 |
| Dorsolateral prefrontal cortex | R | 36 | −16 | 48 | 3.94 | 448 | |
| Middle frontal gyrus | R | 30 | 20 | 58 | 3.67 | 80 | |
| Frontal pole | L | −20 | 68 | −6 | 4.62 | 40 | |
| Temporal | Temporal pole | L | −32 | 8 | −48 | 4.42 | 312 |
| Superior temporal gyrus | L | −48 | −6 | −12 | 3.60 | 88 | |
| Occipital | Lateral occipital cortex | R | 8 | −66 | 66 | 3.77 | 72 |
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All clusters were derived from a VBM analysis. Significant clusters consisted of at 40 mm3 (5 voxels) thresholded at z = 3.3 (p < 0.001), with a peak voxel of z > 3.5 (p < 0.0005). Coordinates are in MNI space and are listed in millimeters.
