Activity-Dependent Tau Protein Translocation to Excitatory Synapse Is Disrupted by Exposure to Amyloid-Beta Oligomers

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Figure 3.
Figure 3.

LTP in hippocampal slices triggers translocalization of tau to CA1 dendritic spines. A, Representative curve of fEPSP slope in percentage of baseline illustrating the LTP induction in CA1 region of hippocampus slices. Sample EPSPs are shown before (1) and after (2) LTP induction. B, Representative Western blots of synaptic protein expression from the CA1 region of hippocampal slices subjected to LTP protocol. C, Quantifications of Western blot from GluA1, actin, and tau in control and LTP conditions (mean ± SEM, 2-tailed Student's t test, *p = 0.0346, **p = 0.0011,***p = 0.0002, N = 4 independent slices).

  1. The Journal of Neuroscience vol. 34 no. 17 6084-6097
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