Attenuation of fibrillar amyloid deposition by the anti-apoE antibody HJ6.3. Seven-month-old female APP/PS1 mice received 10 mg/kg weekly intraperitoneal injections of HJ6.3 or PBS for 21 weeks until 12 months of age. A, Fibrillar amyloid plaques on brain sections of the HJ6.3- or PBS-treated mice were stained with ThioS. Scale bar, 500 μm. B, Quantification of fibrillar amyloid plaque load in cortex, thalamus, and hippocampus (n = 13–17/group; *p < 0.05; **p < 0.01).