Effects of the anti-apoE antibody HJ6.3 on microglial activation. Seven-month-old female APP/PS1 mice received 10 mg/kg weekly intraperitoneal injections of HJ6.3 or PBS for 21 weeks until 12 months of age. Activated microglia in the cortex were immunostained with anti-CD45 antibody (A) and the area covered by CD45 staining was quantified (B) (n = 15–18/group; *p < 0.05). Scale bar, 400 μm.