IL is the primary action site of BDNF mediating CTA extinction. A, Schematic representation of the behavior protocol. Rats received bilateral microinfusion of BDNF followed by coadministration of BDNF antibody in a separate brain region. B, Infusion of BDNF antibody into the IL reversed the BLA BDNF microinfusion-accelerated CTA extinction (n = 9–12 per group). *p < 0.05 versus vehicle group (two-way ANOVA). C, Infusion of BDNF antibody into the BLA has no effect on the IL BDNF microinfusion-accelerated CTA extinction (n = 8–10 per group). *p < 0.05 versus vehicle group (two-way ANOVA). **p < 0.01 versus vehicle group (two-way ANOVA).