Endogenous Opioid-Induced Neuroplasticity of Dopaminergic Neurons in the Ventral Tegmental Area Influences Natural and Opiate Reward

Table 1.

Naloxone administration prior to mating increased latencies to mount and intromission only on the first day of mating

Days Mount latency Intromission latency Ejaculation latency
Saline Naloxone Saline Naloxone Saline Naloxone
1 81 ± 19 334 ± 103* 83 ± 19 343 ± 106* 1378 ± 303 1265 ± 317
2 234 ± 117 163 ± 83 301 ± 119 198 ± 79 598 ± 79 753 ± 198
3 101 ± 40 186 ± 63 134 ± 41 211 ± 68 803 ± 229 753 ± 163
4 110 ± 78 154 ± 105 112 ± 79 195 ± 105 490 ± 122 702 ± 140
5 32 ± 19 14 ± 4 33 ± 19 23 ± 11 524 ± 106 427 ± 75
  • The effect of naloxone was not observed during any of the subsequent mating sessions Data shown are latencies to intromission and ejaculation (seconds) in animals treated either with systemic (s.c.) saline or naloxone (10 mg/kg) during 5 consecutive days (saline, n = 11; naloxone, n = 12). Data for days 1 and 5 are also presented in Figure 4. Data are presented as mean ± SEM;

  • ↵* indicates significant difference between treatments on the same day.

  1. The Journal of Neuroscience vol. 34 no. 26 8825-8836
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