Table 3.
Daily l-DOPA injections restore retinal dopamine levels
| Treatment groups | Sample size | Retinal dopamine level (pg/retina) |
|---|---|---|
| CTRL WT + Veh | 5 | 400 ± 179* |
| CTRL WT + l-DOPA | 5 | 399 ± 179* |
| DM rTHKO + Veh | 6 | 54 ± 22 |
| DM rTHKO + l-DOPA | 8 | 307 ± 109 |
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As expected, rTHKO + Veh mice had significantly reduced DA levels from CTRL mice (post hoc analysis, p < 0.05) and daily injections of l-DOPA (10 mg/kg) were able to increase retinal DA contents of DM rTHKO animals to levels comparable to those of CTRL animals.
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↵*Significant difference between the respective treatment group and the DM rTHKO + Veh group.
