Table 2.
Cell-specific transmembrane receptors and ligands
| Astrocyte | Neuron | OPC | NFO | MO | Microglia | Endothelial | Pericyte | |
|---|---|---|---|---|---|---|---|---|
| Enriched transmembrane receptors | Ptprz1 | Gpc1 | Pdgfra | Gpr17 | Efnb3 | Csf1r | Tfrc | Pdgfrb |
| Ednrb | Ptprn | Gpr17 | Sema4d | Gpr37 | Cd83 | Pglyrp1 | Colec12 | |
| S1pr1 | Caly | Itgav | Plxnb3 | Sema4d | Tyrobp | H2-D1 | Sfrp1 | |
| Fgfr3 | Grin1 | Omg | Ddr1 | Lpar1 | Ccrl2 | Eltd1 | S1pr3 | |
| Gabbr1 | Ptprn2 | Gfra1 | Efnb3 | Ddr1 | B2m | Kdr | Abcc9 | |
| Tnfrsf19 | Gria1 | Gria3 | Gpr37 | Omg | Trem2 | Eng | Rarres2 | |
| Vcam1 | Cnr1 | Sstr1 | Lpar1 | Ephb1 | Sirpa | Tie1 | Pdgfrl | |
| Adcyap1r1 | Opcml | Il1rap | Pdgfra | Gprc5b | Fcer1g | Cav1 | Mrc2 | |
| Gria2 | Stx1b | Adora1 | Omg | S1pr5 | Cd14 | Flt1 | Fas | |
| F3 | Cxadr | Lypd1 | Ephb1 | Gpr17 | Icam1 | Fcgrt | Ednra | |
| Grm3 | Nptxr | Gria4 | Sema5a | Plxnb3 | Cx3cr1 | Sema7a | Lepr | |
| Dag1 | Grm2 | Chrna4 | Il1rap | Gpr62 | Lag3 | Lsr | Osmr | |
| Plxnb1 | Robo2 | Sema5a | S1pr5 | Il1rap | Gpr56 | Acvrl1 | Gprc5 | |
| Ntsr2 | Kit | Calcrl | Prkcz | Prkcz | Itgam | Tek | Ifitm1 | |
| Fgfr1 | Gabrb3 | Gabra3 | Erbb3 | Itgb4 | Fcgr3 | Gpr116 | Ddr2 | |
| Ptch1 | Gabrg2 | Grin3a | Gpr62 | Erbb3 | P2ry12 | Fzd6 | Scarf2 | |
| Fgfr2 | Sarm1 | Oprl1 | Ptpre | Sema5a | P2ry13 | Ptprb | Tgfbr3 | |
| Gpr19 | Gabra2 | Grik4 | Grik3 | Tnfrsf12a | Aplnr | Fzd5 | ||
| Itga6 | Darc | Plxnb3 | Grik2 | H2-K1 | Ptprg | Npy1r | ||
| Gabbr2 | Celsr3 | Grik3 | Casr | Gpr183 | Plxnd1 | Celsr1 | ||
| Enriched ligands | Sparcl1 | Reln | Matn4 | Gsn | Trf | Cst3 | Sparc | Igf2 |
| Cpe | Sst | Scrg1 | Lgi3 | Gsn | C1qa | Sepp1 | Vtn | |
| Cyr61 | Npy | Olfm2 | Scrg1 | Apod | Ccl4 | Pltp | Cxcl12 | |
| Mfge8 | Olfm1 | Vcan | Enpp6 | Lgi3 | Ccl3 | Igfbp7 | Col4a1 | |
| Clu | Dkk3 | Emid1 | Matn4 | Metrn | C1qb | Spock2 | Col1a2 | |
| Htra1 | Ccl27a | Tnr | Tnr | Endod1 | C1qc | Ctla2a | Bgn | |
| Igfbp2 | Cx3cl1 | Nxph1 | Ddr1 | Adamts4 | Selpig | Pglyrp1 | Dcn | |
| Vegfa | Cck | Timp4 | Adamts4 | Cntn2 | Ctsb | Col4a1 | Ptgds | |
| Scg3 | Vgf | Spon1 | Metrn | Enpp6 | B2m | Egfl7 | Cxcl1 | |
| Ncan | Vstm2l | Igsf21 | Fam3c | Hapln2 | Gdf15 | AU021092 | Col1a1 | |
| Pla2g7 | Chgb | Gsn | C1ql1 | Il1rap | Olfm3 | Srgn | Fstl1 | |
| Fjx1 | Scg2 | Fam5c | Vcan | Erbb3 | Tnf | Fn1 | Col3a1 | |
| Timp3 | C1qtnf4 | Qpct | Timp4 | Slpi | Pla2g15 | Kdr | Mdk | |
| Il18 | Cxadr | C1ql3 | Il1rap | Klk6 | Tcn2 | Apln | Igfbp5 | |
| Btbd17 | Col6a2 | Smoc1 | Col11a2 | Col11a2 | Ly86 | Wfdc1 | Serpinf1 | |
| Itih3 | Resp18 | Gpc5 | Bmp4 | Matn4 | Plod1 | Angptl4 | Nbl1 | |
| Hapln1 | Vstm2a | Il1rap | Elfn2 | Dlk2 | Il1a | Htra3 | Nid2 | |
| Lcat | Car11 | Dscam | Dlx2 | Il23a | Tgfb1 | Smpdl3a | Islr | |
| Chrdl1 | Igfbpl1 | Chga | Spon1 | Wnt3 | Lgals9 | Lama4 | Ptx3 | |
| Pla2g3 | Nppc | Nptx2 | Dcam | Npb | Ccl2 | Emcn | Vasn | |
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The top 20 transmembrane receptors and top 20 ligands ranked by fold enrichment of each cell type are listed here. Fold enrichment of astrocytes, neurons, microglia, and endothelial cells are calculated as FPKM of one cell type divided by the average FPKM of all other cell types. Fold enrichment of OPCs, NFOs, and MOs are calculated as FPKM of one cell type divided by the average FPKM of all non-oligodendrocyte-lineage cells to highlight top genes specifically expressed by a particular maturation stage during oligodendrocyte development.
