DOX-mediated increases in phosphorylation of CREB2 in cultured SNs. A, Representative confocal images of pCREB2 immunofluorescence in SNs treated with 2.5 μm DOX for 120 min, in the absence or presence of the p38 MAPK inhibitor SB. Scale bar, 20 μm. B, Summary data. Treatment with 2.5 μm DOX for 120 min induced a significant increase in pCREB2, and this increase was blocked by SB.