Figure 2.
Concomitant PTEN deletion and axonal labeling in PTENf/f;Rosa26-tdTomato mice. Sensorimotor cortex of PTENf/f;Rosa-tdTomato mice, at 1 (A) and 2 (B) weeks after AAV-Cre injection. PTEN is depleted in tdTomato-expressing neurons as early as 1 week after AAV-Cre injection (n = 3). Coronal sections were immunostained with antibodies against PTEN (green) and RFP (red). A, Bottom, Higher-magnification of the boxed areas above. B, Bottom, Higher-magnification of the boxed areas above. Scale bars: (top) A, B, 1000 μm; (bottom) A, B, 100 μm.
