The Journal of Neuroscience Society for Neuroscience

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1. Peripheral mechanisms of CNS disorders

   • Damir Janigro, Professor

   Cleveland Clinic

   I enthusiastically applaud this work for two reasons:

   1) The authors have shown that a systemic mechanism of a brain condition exists and that this may be the best target for a therapeutic intervention. Since most CNS-targeting drugs are difficult to deliver, and given that Kineret and such are large molecular weight protein which do not cross the BBB, the idea that a peripheral IL-1 target may be reached.

   2) The experiments are carefully analyzed and beautifully presented.

   I would like to underscore that we have in the past shown that systemic inflammation is a major player in seizure and psychiatric illness.

   References

   1. Marchi N, Granata T, Janigro D. Inflammatory pathways of seizure disorders. Trends Neurosci 2014;37:55-65.

   2. Janigro D, Iffland PH, Marchi N, Granata T. A role for inflammation in status epilepticus is revealed by a review of current therapeutic approaches. Epilepsia 2013;54 Suppl 6:30-2.

   3. Falcone T, Carlton E, Lee C et al. Does systemic inflammation play a role in pediatric psychosis? Clin Schizophr Relat Psychoses 2013;1-43.

   4. Marchi N, Bazarian JJ, Puvenna V et al. Consequences of repeated blood-brain barrier disruption in football players. PLoS One 2013;8:e56805.

   5. Janigro D. Are you in or out? Leukocyte, ion, and neurotransmitter permeability across the epileptic blood-brain barrier. Epilepsia 2012;53 Suppl 1:26-34.

   6. Marchi N, Johnson AJ, Puvenna V et al. Modulation of peripheral cytotoxic cells and ictogenesis in a model of seizures. Epilepsia 2011;52:1627-34.

   Conflict of Interest:

   None declared

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   Published February 20, 2014