RSD promoted recruitment of peripheral macrophages and increased activation markers on brain CD11b⁺ cells in WT and eIL-1R1kd mice. WT and eIL-1R1kd FVB mice were subjected to RSD or left undisturbed as CON. Brains were collected 14 h after the final cycle and brain CD11b⁺ cells (microglia/macrophages) were isolated. A, Representative flow bivariate dot plots of CD11b/CD45 labeling. B, Average percentage of CD11b⁺/CD45^hi brain macrophages. C, Average proportion of CD14⁺ macrophages. D, Average proportion of CD14⁺ microglia in the brain. Bars represent average ± SEM. *p < 0.05, significantly different from CON.