Brain infusion of DZ causes a precocious emergence of binocular input coincidence and OD plasticity in the pre-CP. A, B, seven-point histograms (left two panels) and the cumulative percentage distribution (right) of ODI of recorded V1 cells from normally reared (blue) and 4 d MD (P15–P19, red) mice, under the condition of daily brain infusion with the vehicle solution (A, Veh) or the solution containing DZ (B), during the pre-CP. The values of CBI are shown in the histogram plots. p values for the comparison between the two cumulative distribution curves in A and B are 0.52 and <10−7, respectively (Kolmogorov–Smirnov test). C, Summary of the onset latency of evoked contralateral (blue) and ipsilateral (red) PSPs by full-field static gratings in V1 binocular cells from pre-CP mice, with or without chronic DZ infusion. p values are calculated by using the Wilcoxon signed-rank test. D, Cumulative distribution of the ipsi–contra latency difference of evoked PSPs in pre-CP mice with different treatments. Significant difference was found between pre-CP and pre-CP-plus-DZ groups (pre-CP+DZ; p < 10−8, Kolmogorov–Smirnov test).
