Context-induced reinstatement of methamphetamine seeking has no effect on Fos-IR in nucleus accumbens. A, Number of Fos-IR nuclei per square millimeter (mean ± SEM) in accumbens core or shell. B, Fos-IR nuclei in accumbens core and accumbens shell captured at 100× magnification. Fos-IR was not different from Extinction Context for the ventral striatum areas quantified (n = 10–12 per group).