Context-Induced Reinstatement of Methamphetamine Seeking Is Associated with Unique Molecular Alterations in Fos-Expressing Dorsolateral Striatum Neurons

(Downloading may take up to 30 seconds. If the slide opens in your browser, select File -> Save As to save it.)

Click on image to view larger version.

Figure 4.
Figure 4.

Local inactivation of dorsolateral but not dorsomedial striatum with muscimol+baclofen decreased context-induced reinstatement of methamphetamine seeking. A, B, Bilateral injections of muscimol+baclofen into (B) dorsolateral striatum, but not (A) dorsomedial striatum, decreased active lever pressing (mean ± SEM) during reinstatement tests in the Methamphetamine Context but not in the Extinction Context (*different from the Vehicle Group, *p < 0.01, n = 7–12 per group). C, D, Dots indicate approximate placements (millimeters from bregma) of injector tips into the (C) dorsomedial or (D) dorsolateral striatum (Paxinos and Watson, 2005).

  1. The Journal of Neuroscience vol. 35 no. 14 5625-5639
Responses to This Article
Be the first to respond to this article
View Similar Articles
Similar articles in this journal»
    Advertisement