All paired datasets of all pharmacological agents and network schematic. A–F, Scatter plots of the percentage change in coupling strength (G_C) for each pair after each drug wash, plotted as a function of baseline coupling strength; pharmacological agents are labeled above and below their respective scatter plots. Gray squares represent pairs with no significant change in coupling strength after drug application. G, Combined data from A–F for all pharmacological agents. Each dot represents a single recorded pair (n = 73 pairs). H, Schematic diagram showing an electrically coupled neuronal circuit. Each oval represents a single neuron, and resistor symbols represent electrical synapses. Dark neurons and synapses represent the “scaffolding network,” with strong electrical coupling, which undergo little to no plasticity. The lighter gray neurons and their electrical synapses represent weak to moderate strength synapses that can effectively be added to or subtracted from the gap junctional network via strengthening or weakening of their synapses.