Alcohol Elicits Functional and Structural Plasticity Selectively in Dopamine D1 Receptor-Expressing Neurons of the Dorsomedial Striatum

Table 1.

Comparison of levels of alcohol consumption and of alcohol preference in transgenic mice used

Mouse lines Alcohol intake (g/kg/24 h) Alcohol preference (%)
D1-eGFP 4.90 ± 0.50 27.88 ± 3.49 n = 11
D1-Cre/DsRed 16.08 ± 1.23 *** 53.69 ± 3.48 ### n = 17
D2-Cre/DsRed 15.88 ± 0.75 a 57.52 ± 1.97 b n = 19
  • All mice were exposed to alcohol using the intermittent access to 20% alcohol two-bottle choice drinking procedure.

  • ↵***p < 0.001, D1-Cre/DsRed versus D1-eGFP mice for alcohol intake;

  • ↵ ### p < 0.001, D1-Cre/DsRed versus D1-eGFP mice for alcohol preference.

  • ↵ a No significant difference (p > 0.05) in alcohol intake between D1-Cre/DsRed and D2Cre/DsRed mice.

  • ↵ b No significant difference (p > 0.05) in alcohol preference between D1-Dre/DsRed and D2-Cre/DsRed mice.

  1. The Journal of Neuroscience vol. 35 no. 33 11634-11643
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