A Single Bolus of Docosahexaenoic Acid Promotes Neuroplastic Changes in the Innervation of Spinal Cord Interneurons and Motor Neurons and Improves Functional Recovery after Spinal Cord Injury

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Figure 6.
Figure 6.

DHA enhances sprouting of corticospinal axons following cervical lateral hemisection in rats. A–C, Photomicrographs of horizontal sections 1000 μm caudal to the lesion site reveal more sprouting of BDA-labeled CST collaterals (arrows) across the midline into the lesion side in the DHA-treated group compared with the vehicle-treated and sham operation group. D, E, Quantitative analysis showed a significant increase in BDA-labeled CST fibers at certain levels of the spinal cord rostral and caudal to the injury on both the lesioned and unlesioned side in DHA-treated animals (red circle) compared with the vehicle-treated animals (blue square). *p < 0.05, DHA versus the vehicle group. **p < 0.01, DHA versus the vehicle group. Scale bar, 100 μm. F–H, No significant difference was found in the number of BDA-labeled CST axons at the C1 dorsal funiculus between the DHA and vehicle-treated groups. ns, Not significant.

  1. The Journal of Neuroscience vol. 35 no. 37 12733-12752
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