Effects of the CB1R antagonist/inverse agonist SR141716 (SR) on palatable food intake in MT/WT animals (a) and adolescent/adult Fischer344 rats (b). A low dose of SR (0.3 mg/kg) was found to significantly attenuate intake of SCM in MT and adolescent Fischer rats to intake levels of WT or adult Fischer rats, respectively, whereas 0.3 mg/kg SR had no effect on SCM intake in WT animals and adult Fischer rats (WT/MT: interaction effect: F_(1,19) = 19.5, p < 0.001; adolescent/adult: interaction effect: F_(1,15) = 11.8, p = 0.004). Effects of SR or vehicle (VEH) on SCM intake were tested in a within-subject design. Data are indicated as means ± SEM (MT: SR/VEH n = 10, WT: SR/VEH n = 11; adolescent: SR/VEH n = 8, adult: SR/VEH = 9; *p ≤ 0.05).