Compromised Dopaminergic Encoding of Reward Accompanying Suppressed Willingness to Overcome High Effort Costs Is a Prominent Prodromal Characteristic of the Q175 Mouse Model of Huntington's Disease

(Downloading may take up to 30 seconds. If the slide opens in your browser, select File -> Save As to save it.)

Click on image to view larger version.

Figure 2.
Figure 2.

NAc dopamine release dynamically encodes reward delivery across PR session in WT mice (n = 8). Mean (+SEM) dopamine concentration across all WT mice aligned to reward delivery (vertical dashed line at 5 s) and divided into thirds of the entire session for each animal. Inset, Mean (+SEM) cyclic voltammograms across all WT mice during the peak dopamine concentration following reward delivery. Bottom, Pseudo-color plots of cyclic voltammograms displaying changes in current across the applied potential (E) plotted over time and averaged across all WT mice.

  1. The Journal of Neuroscience vol. 36 no. 18 4993-5002
Responses to This Article
Be the first to respond to this article
View Similar Articles
Similar articles in this journal»
    Advertisement