Color-coded statistical parametric maps showing clusters where task-related brain activity during “continue” trials scaled positively with cumulative gambling. a, Linear effect of cumulative gambling from the model with serially orthogonalized regressors at the onset of “continue” trials (one-sample t test, n = 18) in ventral striatum and caudate head bilaterally, pre-SMA/MCC/ACC, bilateral IFG extending into anterior insula, and thalamus. All statistical parametric maps are thresholded at an uncorrected p < 0.001. Peak z scores and corresponding stereotactic coordinates are listed in Table 2. b, An ROI analysis (SVC) in STN revealed a significant linear effect of accumulated sum on “continue” activity in right and left STN. For illustration purposes, we show the unthresholded SPM in the bilateral STN mask used for the SVC.