Absence of KCC2 leads to a depolarizing GABA reversal potential. A, Scheme of the PY model with intrinsic currents. B, Ionic pathways in the single-cell model. C, Current via KCC2 cotransporter I_KCC2 as function of extracellular potassium K_OUT⁺ when Cl_IN⁻ = 4 mm and I_KCC2^max = 2 μA/cm². D, Experimental and model voltage traces during GABAergic stimulation. E, Amplitude of the PSP during experimental stimulation (red and blue dots) and in the model (red and blue lines). Experimental traces of D and E are taken from Cohen et al. (2002).