Reduced Efficacy of the KCC2 Cotransporter Promotes Epileptic Oscillations in a Subiculum Network Model

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Figure 5.
Figure 5.

KCC2(−) pathology in the subiculum circuit. A, Raster plot of firing in PYs and INs during seizure initiation. B, LFP computed from the network and experimental LFP recordings. C, Extracellular potassium, KOUT+, and intracellular chloride, ClIN−, changes during seizure initiation. D, Power spectrum of the LFP from the model and experimental recordings.

  1. The Journal of Neuroscience vol. 36 no. 46 11619-11633
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