Post-TBI administration of the nAChRa7 agonist PNU-282987 decreases the infiltration of inflammatory cells into the injured brain. A, Timeline for CCI, drug administration, and tissue collection after TBI. B, Photomicrographs of tissue taken from sham, vehicle-treated injured (CCI-vehicle) and PNU-282987-treated injured (CCI-α7^agonist) animals demonstrating MPO and CCR2 immunoreactivity in the pericontusion area of the cortex 48 h after injury. C, Quantification of MPO-positive cells in the injured ipsilateral cortex after PNU-282987-treatment. D, Quantification of CCR2-positive cells in the injured ipsilateral cortex after PNU-282987-treatment. *p < 0.05. Data are presented as the mean ± SEM. Scale bar, 100 μm.