Connexin-Mediated Signaling in Nonsensory Cells Is Crucial for the Development of Sensory Inner Hair Cells in the Mouse Cochlea

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Figure 6.
Figure 6.

IHCs from Cx30Δ/Δ knock-out mice develop normally. A, Potassium currents recorded from mature IHCs (P25) of Cx30Δ/Δ knock-out mice using the same voltage protocol described in Figure 3. Inset, The presence of IK,f is evident. B, Current-voltage curves measured from IHCs at 2 ms from the stimulus onset of Cx30Δ/Δ (n = 6, P25), wild-type (Cx30+/+: n = 10, P16–P18), and Cx30(−/−) (Cx30−/−: n = 9, P16–P18) mice. C, Voltage responses recorded from a mature IHC of a Cx30Δ/Δ mouse, which were elicited by applying hyperpolarizing and depolarizing current injections. Recordings were performed at room temperature.

  1. The Journal of Neuroscience vol. 37 no. 2 258-268
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