Allometric Analysis Detects Brain Size-Independent Effects of Sex and Sex Chromosome Complement on Human Cerebellar Organization

Table 3.

Allometrically corrected effects of sex and SCA on regional cerebellar anatomy

Volume Wilcoxon test p values for group differences
Versus XX Versus XY
XXX XXY XYY XXYY
TCbV <0.0001 <0.0001 0.0005 <0.0001
Hemispheres <0.0001 <0.0001 0.0003 <0.0001
Vermis 0.0114 0.4309 0.1431 0.0001
Flocculus 0.3950 0.0027 1.0000 0.0359
Anterior 0.0679 0.0015 0.2028 0.0003
Superior posterior 0.0003 <0.0001 0.0043 <0.0001
Inferior posterior 0.0008 <0.0001 0.0166 <0.0001
Lobule III 0.0571 <0.0001 0.1780 <0.0001
Lobule IV 0.0079 0.0088 0.0136 0.0444
Lobule V 0.0594 0.1884 0.7230 0.0025
Lobule VI 1.0000 0.6716 1.0000 1.0000
Crus I 0.0022 <0.0001 0.0002 <0.0001
Crus II 0.0002 <0.0001 0.0974 <0.0001
Lobule VIIB 0.0006 <0.0001 0.0727 <0.0001
Lobule VIIIA 0.0003 <0.0001 0.4884 0.0015
Lobule VIIIB 0.0293 0.0096 0.5019 0.0039
Lobule IX 0.1041 0.0212 0.0061 0.0013
  • Table of Bonferroni-corrected p values for observed cerebellar volume reductions in SCA groups relative to gonadal controls within the core sample after correction for aTBV using independently derived allometric norms. Bold values are statistically significant.

  1. The Journal of Neuroscience vol. 37 no. 21 5221-5231
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