AgRP neuron stimulation is sufficient to increase feeding following administration of noninflammatory anorexigenic compounds. Stimulation of AgRP neurons rapidly and reversibly increased cumulative food intake (left) and mean feeding rate (right) following administration of saline (A, B), amylin (C, D), CCK (E, F), and LiCl (G, H), but not following administration of LPS (I, J). Blue background represents the 20 min photostimulation period. All values represent the mean ± SEM, black dots represent individual animals (n = 5 animals per group). K, Total food consumed before stimulation of AgRP neurons across conditions. L, Total food consumed during stimulation of AgRP neurons across conditions. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001, Bonferroni post hoc tests between groups; n.s., not significant.