Model of functional anatomy of AgRP neuron projections. AgRP neurons increase food intake by projecting to downstream populations (green connections) that initiate feeding including the bed nucleus of the stria terminalis (BNST), lateral hypothalamus (LH), paraventricular hypothalamic nucleus (PVH), and paraventricular thalamic nucleus (PVT). AgRP neurons also inhibit other nonfeeding behavioral/physiological states by projecting to downstream regions (red connections) such as the MeA to inhibit fear and aggression or arcuate kisspeptin neurons (Kiss) to inhibit reproduction. Our results demonstrate that AgRP neurons disengage noninflammatory appetite-suppressing states by projecting to the PBN (dark red connections).