MACO-1 and SCD-2/HEN-1 function in the distinct signaling pathway. A, Retention of adaptation to diacetyl in wild-type and in maco-1 (qj143); scd-2 (ok565), and each single mutant (n ≥ 8, 2-way ANOVA, F_{strain(2,132)} = 457.2, p = 0.0049). B, Retention of adaptation to isoamyl alcohol in wild-type, maco-1 (qj143), scd-2 (qj141), and hen-1 (tm501) animals (n ≥ 6). **p < 0.01; post hoc t test with Bonferroni's correction (A) or Student's t test (B). Error bars represent SEM.