A model for regulation of forgetting of olfactory adaptation to diacetyl. The genetic epistasis analyses in this study showed that MACO-1 and SCD-2 regulate forgetting of olfactory adaptation to diacetyl downstream of the TIR-1/JNK-1 pathway, and calcium imaging analyses suggested that MACO-1 might be involved in two distinct manners upstream of neural secretion of AWA and downstream of AWA sensation, and that SCD-2 functions for forgetting in AWA sensory neurons.