Normal locomotion and anxiety-like behavior in Lrfn2^−/− mice. A, B, Normal locomotor activity and anxiety-like behavior of Lrfn2^−/− mice (3 months) in open-field tests at two different light intensities (110 and 0 lux), as shown by distance moved and time spent in the center region of the open-field arena. n = 13 mice for WT and 14 mice for KO (110 lux), and 13 for WT and 16 for KO (0 lux). NS, repeated-measures two-way ANOVA and Student's t test. C, Normal locomotor activity of Lrfn2^−/− mice (2 months) in LABORAS cages, where mouse movements were monitored for 3 consecutive days. n = 13 for WT and 16 for KO. NS, repeated-measures two-way ANOVA. D, Normal anxiety-like behavior of Lrfn2^−/− mice (4 months) in the elevated plus-maze test. n = 14 for WT and 17 for KO. NS, Student's t test. E, Normal anxiety-like behavior of Lrfn2^−/− mice (4 months) in the light/dark test. n = 14 for WT and 16 for KO. NS, Student's t test.