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Asymmetric Turnover Dynamics of Nav1.6 Voltage-Gated Sodium Channels at the Axon Initial Segment bioRxiv, 18 September 2026, 0(2026):2026.09.10.747750v1-2026.09.10.747750
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Paralemmin-2 is a membrane-anchored cytoskeletal constituent of Axon Initial Segments and nodes of Ranvier bioRxiv, 9 September 2026, 0(2026):2026.09.03.749080v1-2026.09.03.749080
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Tau isoforms modulate the axon initial segment controlling axonal trafficking and neuronal excitability bioRxiv, 5 September 2026, 0(2026):2026.09.01.745409v1-2026.09.01.745409
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Altered axonal initial segment development links circuit and Kv7 dysfunction in an Fmr1 knockout rat bioRxiv, 26 August 2026, 0(2026):2026.08.18.745439v1-2026.08.18.745439
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Paralemmin 2 is a shared, alternatively-spliced regulator of axon initial segments and paranodal junctions in oligodendrocytes
bioRxiv, 26 August 2026, 0(2026):2026.08.18.745582v1-2026.08.18.745582
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CRISPR/Cas9-based knockout screening revealed GSK3{beta} as a regulator of axon initial segment structural plasticity bioRxiv, 26 June 2026, 0(2026):2026.05.21.726787v3-2026.05.21.726787
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Deeper neuronal and glial proteomic insights using an optimized pipeline for proximity labeling proteomics bioRxiv, 27 January 2026, 0(2026):2026.01.21.700735v1-2026.01.21.700735
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A neuron type-specific microexon in Ank3/ankyrin-G modulates calcium activity and neuronal excitability bioRxiv, 17 December 2025, 0(2025):2025.12.12.693948v2-2025.12.12.693948
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Bringing Chandelier Cells Out of the Shadows: Exploring the Development of a Unique Neuron Type in the Brain Cold Spring Harbor Perspectives in Biology, 1 November 2025, 17(11):a041506
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Absence of short-term axon initial segment plasticity in human, mouse, and rat cortical circuits bioRxiv, 5 September 2025, 0(2025):2025.09.01.672986v1-2025.09.01.672986
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Essential role of astrocytes in rapid activity-dependent restructuration of the axon initial segment bioRxiv, 7 August 2025, 0(2025):2025.07.31.667937v3-2025.07.31.667937
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Specialized axon initial segment enables low firing threshold and rapid action potential output in fast-spiking interneurons
of the human neocortex bioRxiv, 25 July 2025, 0(2025):2024.10.28.620622v2-2024.10.28.620622
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Ex Vivo Functional Characterization of Mouse Olfactory Bulb Projection Neurons Reveals a Heterogeneous Continuum eneuro, 1 March 2025, 12(3):ENEURO.0407-24.2025
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Mitochondria transported by Kinesin 3 prevent localized calcium spiking to inhibit caspase-dependent specialized cell death
bioRxiv, 15 January 2025, 0(2025):2025.01.08.631976v1-2025.01.08.631976
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A Topological Study of a Surface Signaling Network and Possible Implications for Neural Dynamics bioRxiv, 6 January 2025, 0(2025):2022.08.01.502331v4-2022.08.01.502331
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Variability of axon initial segment geometry and its impact on hippocampal pyramidal cell function bioRxiv, 20 December 2024, 0(2024):2024.12.16.628625v1-2024.12.16.628625
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TRIM46 Is Required for Microtubule Fasciculation In Vivo But Not Axon Specification or Axon Initial Segment Formation Journal of Neuroscience, 16 October 2024, 44(42):e0976242024
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The transcriptional response of cortical neurons to concussion reveals divergent fates after injury bioRxiv, 20 September 2024, 0(2024):2024.02.26.581939v3-2024.02.26.581939
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Prenatal exposure to valproic acid induces sex-specific alterations in cortical and hippocampal neuronal structure and function
in rats bioRxiv, 6 September 2024, 0(2024):2024.09.03.611039v1-2024.09.03.611039
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Ex vivo functional characterization of mouse olfactory bulb projection neurons reveals a heterogenous continuum bioRxiv, 24 July 2024, 0(2024):2024.07.17.603915v1-2024.07.17.603915
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Dichotomy between extracellular signatures of active dendritic chemical synapses and gap junctions bioRxiv, 10 July 2024, 0(2024):2024.07.04.602060v1-2024.07.04.602060
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Axonal Tau sorting depends on the PRR2 domain and 0N4R-specific interactions hint at distinct roles of Tau isoforms in synaptic
plasticity bioRxiv, 6 July 2024, 0(2024):2024.06.28.601286v1-2024.06.28.601286
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Live imaging of excitable axonal microdomains in ankyrin-G-GFP mice bioRxiv, 22 June 2024, 0(2024):2023.02.01.525891v2-2023.02.01.525891
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TRIM46 is not required for axon specification or axon initial segment formation in vivo bioRxiv, 27 May 2024, 0(2024):2024.05.23.595556v1-2024.05.23.595556
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Loss of Intracellular Fibroblast Growth Factor 14 (iFGF14) Increases the Excitability of Mature Hippocampal and Cortical Pyramidal
Neurons bioRxiv, 8 May 2024, 0(2024):2024.05.04.592532v1-2024.05.04.592532
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Aberrant axon initial segment is an indicator for task-independent neural activity in autism model mice bioRxiv, 19 February 2024, 0(2024):2024.02.15.580571v1-2024.02.15.580571
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Changes in mitochondrial distribution occur at the axon initial segment in association with neurodegeneration in Drosophila
bioRxiv, 17 February 2024, 0(2024):2024.02.14.580288v1-2024.02.14.580288
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Unveiling the cell biology of hippocampal neurons with dendritic axon origin bioRxiv, 18 January 2024, 0(2024):2023.09.14.557747v2-2023.09.14.557747
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The actin-spectrin submembrane scaffold restricts endocytosis along proximal axons bioRxiv, 22 December 2023, 0(2023):2023.12.19.572337v1-2023.12.19.572337
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Dysfunctional parvalbumin interneurons in a genetic mouse model of schizophrenia bioRxiv, 14 September 2023, 0(2023):2023.09.10.557034v1-2023.09.10.557034
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Axon Initial Segment GABA Inhibits Action Potential Generation throughout Periadolescent Development Journal of Neuroscience, 13 September 2023, 43(37):6357-6368
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Sub-membrane actin rings compartmentalize the plasma membrane bioRxiv, 26 August 2023, 0(2023):2023.08.22.554239v1-2023.08.22.554239
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Sodium channel endocytosis drives axon initial segment plasticity bioRxiv, 28 July 2023, 0(2023):2022.11.09.515770v3-2022.11.09.515770
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Sodium channel endocytosis drives axon initial segment plasticity bioRxiv, 17 June 2023, 0(2023):2022.11.09.515770v2-2022.11.09.515770
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{alpha}-synuclein promotes neuronal dysfunction and death by disrupting the binding of ankyrin to ss-spectrin bioRxiv, 9 June 2023, 0(2023):2023.06.02.543481v1-2023.06.02.543481
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Coordination of Pickpocket ion channel delivery and dendrite growth in Drosophila sensory neurons bioRxiv, 1 June 2023, 0(2023):2022.05.19.492359v2-2022.05.19.492359
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Neuron cilia constrain glial regulators to microdomains around distal neurons bioRxiv, 22 March 2023, 0(2023):2023.03.18.533255v1-2023.03.18.533255
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Antibody-directed extracellular proximity biotinylation reveals Contactin-1 regulates axo-axonic innervation of axon initial
segments bioRxiv, 9 March 2023, 0(2023):2023.03.06.531378v1-2023.03.06.531378
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The Amyloid Precursor Protein Modulates the Position and Length of the Axon Initial Segment Journal of Neuroscience, 8 March 2023, 43(10):1830-1844
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{alpha}-Synuclein Promotes Neuronal Dysfunction and Death by Disrupting the Binding of Ankyrin to {beta}-Spectrin Journal of Neuroscience, 1 March 2023, 43(9):1614-1626
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Disease-causing Slack potassium channel mutations produce opposite effects on excitability of excitatory and inhibitory neurons
bioRxiv, 17 February 2023, 0(2023):2023.02.14.528229v1-2023.02.14.528229
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NaV1.7 mRNA and protein expression in putative projection neurons of the human spinal dorsal horn bioRxiv, 8 February 2023, 0(2023):2023.02.04.527110v1-2023.02.04.527110
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CDK5/p35-Dependent Microtubule Reorganization Contributes to Homeostatic Shortening of the Axon Initial Segment Journal of Neuroscience, 18 January 2023, 43(3):359-372
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Axon Initial Segments Are Required for Efficient Motor Neuron Axon Regeneration and Functional Recovery of Synapses Journal of Neuroscience, 26 October 2022, 42(43):8054-8065
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Structural plasticity of axon initial segment in spinal cord neurons underlies inflammatory pain bioRxiv, 26 July 2022, 0(2022):2022.07.24.501281v1-2022.07.24.501281
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Physical and functional convergence of the autism risk genes Scn2a and Ank2 in neocortical pyramidal cell dendrites bioRxiv, 3 June 2022, 0(2022):2022.05.31.494205v2-2022.05.31.494205
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Coordination of Pickpocket ion channel delivery and dendrite growth in Drosophila sensory neurons bioRxiv, 23 May 2022, 0(2022):2022.05.19.492359v1-2022.05.19.492359
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Pathogenic TDP-43 Disrupts Axon Initial Segment Structure and Neuronal Excitability in a Human iPSC Model of ALS bioRxiv, 19 May 2022, 0(2022):2022.05.16.492186v1-2022.05.16.492186
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AnkG-Neurofascin complex structure reveals binding mechanisms required for integrity of the AIS bioRxiv, 30 April 2022, 0(2022):2022.04.27.489743v1-2022.04.27.489743
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CRISPR activation rescues abnormalities in SCN2A haploinsufficiency-associated autism spectrum disorder bioRxiv, 4 April 2022, 0(2022):2022.03.30.486483v1-2022.03.30.486483
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Direct fluorescent labeling of NF186 and NaV1.6 in living primary neurons using bioorthogonal click chemistry bioRxiv, 6 March 2022, 0(2022):2022.03.01.480798v1-2022.03.01.480798
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Characterisation of TRIM46 autoantibody-associated paraneoplastic neurological syndrome Journal of Neurology, Neurosurgery & Psychiatry, 1 February 2022, 93(2):196-200
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The amyloid precursor protein modulates the position and length of the axon initial segment offering a new perspective on
Alzheimers disease genetics bioRxiv, 27 January 2022, 0(2022):2022.01.23.477413v1-2022.01.23.477413
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Pax6 loss alters the morphological and electrophysiological development of mouse prethalamic neurons bioRxiv, 28 July 2021, 0(2021):2021.03.22.436455v2-2021.03.22.436455
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Functional Microstructure of CaV-Mediated Calcium Signaling in the Axon Initial Segment Journal of Neuroscience, 28 April 2021, 41(17):3764-3776
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Altered action potential waveform and shorter axonal initial segment in hiPSC-derived motor neurons with mutations in VRK1
bioRxiv, 5 April 2021, 0(2021):2021.04.01.438138v1-2021.04.01.438138
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Emergence of directional bias in tau deposition from axonal transport dynamics bioRxiv, 24 March 2021, 0(2021):2021.03.22.436470v1-2021.03.22.436470
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Endogenously expressed Ranbp2 is not at the axon initial segment Journal of Cell Science, 11 March 2021, 134(6):jcs256180
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Brief Sensory Deprivation Triggers Cell Type-Specific Structural and Functional Plasticity in Olfactory Bulb Neurons Journal of Neuroscience, 10 March 2021, 41(10):2135-2151
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Dopamine Transporter Localization in Medial Forebrain Bundle Axons Indicates Its Long-Range Transport Primarily by Membrane
Diffusion with a Limited Contribution of Vesicular Traffic on Retromer-Positive Compartments Journal of Neuroscience, 13 January 2021, 41(2):234-250
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Functional microstructure of CaV-mediated calcium signaling in the axon initial segment bioRxiv, 16 November 2020, 0(2020):2020.11.13.382374v1-2020.11.13.382374
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The Palmitoyl Acyltransferase ZDHHC14 Controls Kv1-Family Potassium Channel Clustering at the Axon Initial Segment bioRxiv, 13 November 2020, 0(2020):2020.11.11.378240v1-2020.11.11.378240
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Glycinergic axonal inhibition subserves acute spatial sensitivity to sudden increases in sound intensity bioRxiv, 31 October 2020, 0(2020):2020.10.27.358085v1-2020.10.27.358085
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Axonal TAU sorting requires the C-terminus of TAU but is independent of ANKG and TRIM46 enrichment at the AIS bioRxiv, 26 September 2020, 0(2020):2020.06.26.173526v2-2020.06.26.173526
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Single-dose ethanol intoxication causes acute and lasting neuronal changes in the brain bioRxiv, 11 September 2020, 0(2020):2020.09.09.289256v1-2020.09.09.289256
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Structural and Functional Refinement of the Axon Initial Segment in Avian Cochlear Nucleus during Development Journal of Neuroscience, 26 August 2020, 40(35):6709-6721
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Spike-frequency dependent inhibition and excitation of neural activity by high-frequency ultrasound bioRxiv, 20 August 2020, 0(2020):2020.06.01.128710v2-2020.06.01.128710
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The axonal sorting activity of pseudorabies virus Us9 protein depends on the state of neuronal maturation bioRxiv, 11 August 2020, 0(2020):2020.08.06.239384v1-2020.08.06.239384
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Brief sensory deprivation triggers cell type-specific structural and functional plasticity in olfactory bulb neurons bioRxiv, 14 May 2020, 0(2020):2020.05.10.086926v1-2020.05.10.086926
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Quantitative mapping of transcriptome and proteome dynamics during polarization of human iPSC-derived neurons bioRxiv, 25 April 2020, 0(2020):2020.04.21.052498v1-2020.04.21.052498
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Chandelier cell anatomy and function reveal a variably distributed but common signal bioRxiv, 4 April 2020, 0(2020):2020.03.31.018952v1-2020.03.31.018952
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Sensory input drives rapid homeostatic scaling of the axon initial segment in mouse barrel cortex bioRxiv, 2 March 2020, 0(2020):2020.02.27.968065v1-2020.02.27.968065
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Intrinsic temporal tuning of neurons in the optic tectum is shaped by multisensory experience bioRxiv, 21 December 2019, 0(2019):540898v1-540898
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Axonal transport: Driving synaptic function Science, 11 October 2019, 366(6462):eaaw9997
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An unfolding role for ankyrin-G at the axon initial segment PNAS, 24 September 2019, 116(39):19228-19230
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Neurodevelopmental mutation of giant ankyrin-G disrupts a core mechanism for axon initial segment assembly PNAS, 24 September 2019, 116(39):19717-19726
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Ankyrin-G induces nucleoporin Nup358 to associate with the axon initial segment of neurons Journal of Cell Science, 15 September 2019, 132(18):jcs222802
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Deletion of Class II ADP-Ribosylation Factors in Mice Causes Tremor by the Nav1.6 Loss in Cerebellar Purkinje Cell Axon Initial
Segments Journal of Neuroscience, 7 August 2019, 39(32):6339-6353
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Vectashield-induced fluorescence quenching hinders conventional and super resolution microscopy bioRxiv, 19 June 2019, 0(2019):393264v3-393264
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Ultrastructure of the axonal periodic scaffold reveals a braid-like organization of actin rings bioRxiv, 29 May 2019, 0(2019):636217v2-636217
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The model of local axon homeostasis - explaining the role and regulation of microtubule bundles in axon maintenance and pathology
bioRxiv, 24 May 2019, 0(2019):577320v3-577320