Intraplantar injection of TLR9 antagonist ODN 2088 reverses PTX-induced mechanical allodynia in female nude mice. Intraplantar injection of 10 μg ODN 2088 increased paw withdrawal threshold in PTX-treated female nude mice (after PTX day 12). ***p < 0.05 compared with BL. ^#p < 0.05 compared with vehicle group. Two-way ANOVA with Bonferroni's post hoc test; n = 5 mice per group. Data are mean ± SEM.