Dynamics of the impact of SIV infection and ART regimen on Syn I phosphorylations. A, Amino acid residues studied in this work and their approximate positions in the Syn I domains (A–E). B, Observed changes in phosphorylations at multiple sites of Syn I in total lysates versus synaptosome preparations and functional impact of phosphorylation of these sites in normal physiological conditions based on Cesca et al. (2010). Thin arrows indicate insignificant trends. Thick arrows indicate significant changes. NC, No changes; AA, amino acids; NT, neurotransmitter.