Post hoc cross-lagged panel model results with longitudinal MMSE scores in (A) HC and (B) AD/MCI subjects. PET-derived Aβ burden, CSF p-tau concentration, CSF Aβ42 concentrations, and MMSE scores are modeled across three waves (baseline, 24 months, and 48 months) with covariates sex, baseline age, APOEε4, and baseline whole-brain atrophy. Legend as in Figure 2. Standardized coefficients (β) and p values are displayed for all significant longitudinal predictions between MMSE scores and other cross-lagged variables, and for all significant associations between baseline covariates and MMSE scores. The complete covariance and correlation matrices are provided for HC in Figure 4-1, and in Figure 4-2, and for AD/MCI in Figure 4-3 and Figure 4-4.