Table 2.
Summary of findings in healthy elderly and AD/MCI groups
| Longitudinal predictive results | Cross-sectional correlations | |
|---|---|---|
| Healthy elderly | • Lower CSF Aβ42 predicted increased Aβ deposition | • Negative correlation between CSF Aβ42 and Aβ burden |
| • Greater Aβ burden variably predicted lower CSF Aβ42 (not in the Aβ− subgroup) | • Positive correlation between CSF p-tau and Aβ burden | |
| • Lower CSF Aβ42 predicted increased CSF p-tau | • Positive correlation between CSF Aβ42 and CSF p-tau (the Aβ− subgroup only) | |
| • Higher CSF p-tau predicted increased Aβ deposition | • Negative correlation between Aβ burden and MMSE scores at 48 months | |
| • Lower CSF Aβ42 variably predicted lower MMSE scores | ||
| AD/MCI | • Lower CSF Aβ42 predicted increased Aβ deposition | • Negative correlation between CSF Aβ42 and Aβ burden |
| • Greater Aβ burden predicted lower CSF Aβ42 | • Positive correlation between CSF p-tau and Aβ burden | |
| • Greater Aβ burden predicted lower MMSE scores | • Positive correlation between CSF Aβ42 and MMSE scores | |
| • Higher CSF p-tau concentrations variably predicted lower MMSE scores | • Negative correlation between CSF p-tau and MMSE scores | |
| • Negative correlation between Aβ burden and MMSE scores |
