Elevating brain estrogen increases DAergic fiber densities and benefits motor behavior in 3K mice. a, Representative images of TH⁺ nerve terminals and VMAT2 in 3K-Sham, 3K-DHED males and 3K females and WT females (n = 4 each group). b, c, Relative TH and VMAT2 optical density was analyzed in the dorsal CPu. d, Pharmacological rescue of motor deficits of male 3K mice by DHED: increase in pole climbing performance after 90 d and (e) fine motor skill on the accelerating rotarod and (f) increased the 2- to 3-feet body support on a treadmill. g, Rotarod, and (h) DHED benefit in wire performance in female 3K mice. Data are mean ± SEM. Two-way ANOVA post Tukey: *p < 0.05; **p < 0.01. Scale bar, 50 μm.