Ror2 and Ryk mediate spinal Wnt5a-induced dendritic spine remodeling. A, B, Quantification of synaptic spine density in spinal dorsal horn neurons of primarily lamina V origin in mice intrathecally injected with recombinant mouse Wnt5a and receiving siRNA against Ror2 (A), siRNA against Ryk (B), or the respective scrambled siRNA controls (A, B). N =3–4 mice/condition. Two-way ANOVA for random measures, followed by Bonferroni's test, was performed. *p < 0.05 compared with the corresponding control group; †p < 0.05 compared with Wnt5a-treated mice. In all panels, data are represented as the mean ± SEM. C, Typical examples of high-magnification views of microscopic images of Golgi-labeled dendrites with synaptic spines in mice from the above groups. Scale bar, 10 μm.