Spinal Ror2 contribute to nociceptive hypersensitivity in mouse models of chronic pain. A–D, Behavioral analysis of the effects of intrathecal administration of siRNA against Ror2 on mechanical sensitivity 24 h after intraplantar injection of CFA-induced unilateral paw inflammation (A, B) or 7 d after unilateral nerve injury (SNI; C, D). Stimulus–response curves of the ipsilateral paw are shown in A and C, whereas the integral over time (AUC) for the inflamed or injured paw (ipsilateral) as well as the contralateral paw are shown in B and D. In all panels, N = 8 mice/group; ANOVA for repeated measures was performed, followed by Tukey's test; *p < 0.05 compared with the corresponding control group; †p < 0.05 compared with CFA-treated (A, B) or SNI-treated (C, D) animals. In all panels, data are represented as the mean ± SEM, and bar graphs are also shown as scatter plots.