Anterior cingulate axons (blue) in subgenual cingulate cortex form synapses with excitatory (green) and inhibitory neurons (pink, cell soma; orange, aspiny dendrite). Dense synapses seen at high resolution suggest the anterior cingulate has a powerful impact on subgenual cingulate for the regulation of emotions. The image is a 3D reconstruction from high-throughput electron microscopy using 200 serial sections spanning 10 μm. For more information, see the article by Joyce et al. (pages 8306–8328). Cover Image: Jess Holz (artist).