TBS CA1 LTP is enhanced in germline Arc KO animals. A, There was no significant difference in the magnitude of LTP over the first 5 min poststimulation between the Arc^GFP/GFP, KO (red circles), and WT (black circles) littermates, but the magnitude of LTP was significantly greater in Arc^GFP/GFP KO mice compared with WT littermates over the last 5 min of recording, when LTP was induced using a theta-burst stimulation protocol (4 trains at 10 s intertrain intervals; each train consisted of 10 bursts at 5 Hz, with each burst containing 4 stimuli at 100 Hz). B, Basal synaptic transmission was significantly weaker in Arc^−/− KO (blue circles) mice compared with WT (black circles) littermates. C, The magnitude of LTP over the first 5 min postsimulation, and over the last 5 min of recording, was significantly greater in the Arc^−/− KO (blue circles) mice compared with WT (black circles) littermates when LTP was induced using a theta-burst stimulation protocol (4 trains at 10 s inter-train intervals; each train consisted of 10 bursts at 5 Hz, with each burst containing 4 stimuli at 100 Hz). Data are represented as mean ± SEM. Scale bars: 0.5 mV (horizontal) and 5 ms (vertical).