AMPA/NMDA ratio was not affected by early inflammation induced by LPS. A, B, Sample scaled traces of AMPA currents recorded at −70 mV and NMDA currents at +40 mV of CA1 pyramidal cells evoked by stimulation of afferent fibers in the Schaffer collateral pathway (as indicated on schematic on left) from adult female (A) and male (B) mice early exposed to Veh (dark traces) or LPS (green/blue traces) at P14. Calibration: 100 pA, 50 ms. Scatter graphs on right show the AMPA/NMDA ratio of individual cells. Summary data display no significant differences in the AMPA/NMDA ratio in pyramidal neurons from both female (green symbols) and male (blue symbols) mice early exposed to inflammation compared with controls (white symbols). Horizontal lines are the mean (n = 13–19 cells, 7–8 mice/group). SO, Stratum oriens; PTX, picrotoxin.