APP deficiency does not affect basic functional properties of cultured dentate granule cells. A, B, Sample traces and group data of sEPSCs recorded from dentate granule cells of APP^+/+ and APP^−/− tissue cultures (APP^+/+, n = 10 cells from 4 cultures; APP^−/−, n = 20 cells from 6 cultures; Mann–Whitney test). C, D, Sample traces and group data of sIPSCs from granule cells of APP^+/+ and APP^−/− tissue cultures (APP^+/+, n = 12 cells from 4 cultures; APP^−/−, n = 18 cells from 6 cultures; Mann–Whitney test). E–G, Sample traces and group data for input-output properties of dentate granule cells of APP^+/+ and APP^−/− tissue cultures. RMP, Resting membrane potential; AP, action potential. APP^+/+, n = 19 cells from 5 cultures; APP^−/−, n = 20 cells from 5 cultures (Mann–Whitney test and two-way ANOVA). Data are mean ± SEM. NS, Not significant.