Dopamine Transporter Is a Master Regulator of Dopaminergic Neural Network Connectivity

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Figure 3.
Figure 3.

SNC and VTA exhibit similar patterns of dynamic functional connectivity. Intrinsic dynamic functional connectivity of dopamine neurons of the SN (SNC) and VTA exhibit similar patterns of functional connectivity. Functional connectivity is defined as the average pairwise Spearman's correlation across all neuronal pairs. A, Representative dynamic connectivity in the SN and VTA. B, Mean functional connectivity is similar in the SN and VTA (mean FC = 0.386, 0.407 SNC, VTA, respectively, two-tailed unpaired t test, p = 0.7193). C, Variability of functional connectivity (coefficient of variation, CV) is similar across the two regions (mean CV = 0.694,0.673 SNC, VTA, respectively, two-tailed unpaired t test, p = 0.6887); n = 5–8 sections from 5 animals.

  1. The Journal of Neuroscience vol. 41 no. 25 5453-5470
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