Chronic Augmentation of Endocannabinoid Levels Persistently Increases Dopaminergic Encoding of Reward Cost and Motivation

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Figure 7.
Figure 7.

MAGL inhibition does not alter consumption or locomotion. a–c, JZL (8 mg/kg, i.p.) treatment across two consecutive sessions (S1, S2) did not alter free-access sucrose consumption (two-way RM ANOVA; treatment: F(1,34) = 0.52, p = 0.475; a) or open-field locomotion measured by distance traveled (two-way RM ANOVA; treatment: F(1,34) = 1.42, p = 0.249; b) and movement velocity (two-way RM ANOVA; treatment: F(1,34) = 1.42, p = 0.249; c). Post hoc comparison following significant main effect of time, S1 vs S2, ***p < 0.001.

  1. The Journal of Neuroscience vol. 41 no. 32 6946-6953
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