The phenotype of obese mice submitted to overexpression of NHLH2 in the hypothalamus. In mice submitted to the protocol depicted in Figure 11A, the transcript expressions of Adgre1 (gene coding for F4/80) (A), Ccl2 (gene coding for MCP1) (B), and Il1b (C) were determined in the epidydimal white adipose tissue; the transcript expressions of Pomc (D) and Cart (E) were determined in the hypothalamus; the transcripts of Adgre1 (gene coding for F4/80) (F), Ccl2 (gene coding for MCP1) (G), and Il1b (H) were determined in the BAT; liver histology is depicted in I, and the transcripts of Adgre1 (gene coding for F4/80) (J) and Il1b (K) were determined in the liver. *p < 0.05 versus SC4h. eWAT, Epididymal white adipose tissue; OE, overexpression; OE4h, overexpression fed on HFD for 4 weeks before lentivirus injection and maintained on HFD thereafter until the end of the experimental period; SC, scrambled; SC4h, scrambled fed on HFD for 4 weeks before lentivirus injection and maintained on HFD thereafter until the end of the experimental period. In al experiments, n = 5 or 6.