Behavioral changes induced by the overexpression of NHLH2 in the hypothalamus of obese mice. Mice submitted to the protocol depicted in Figure 11A were evaluated in the open field test (A-C), elevated cross maze (D,E), tail suspension test (F,G), time spent on the treadmill (H), and maximum RPM in the rotarod test (I). *p < 0.05 versus SC4h. ^#p < 0.05 versus OE4h. OE, Overexpression; OE4h, overexpression fed an HFD for 4 weeks before lentivirus injection and maintained on an HFD thereafter until the end of the experimental period; SC, scrambled; SC4h, scrambled fed an HFD for 4 weeks before lentivirus injection and maintained on an HFD thereafter until the end of the experimental period. In all experiments, n = 5-8.