NHLH2 transcriptional targets. A, The heatmap in the left-hand part of the figure represents the presence or absence of binding site motifs for NHLH2 in putative gene targets. Genes and number of NHLH2 binding motifs are depicted in the tables. One gene target may present more than one of each of the binding motifs; hence, the number of NHLH2 binding motifs may be >5. B, Graphic representation of the 50 major NHLH2 transcriptional targets determined using the GRNs. C, NHLH2 hypothalamic targets identified in the BXD mice families.