Liver histology and inflammatory markers in mice under simultaneous introduction of an HFD and induction of overexpression of NHLH2 in the hypothalamus. Liver histology of mice treated according to the protocol depicted in Figure 6E and fed on an HFD (A) or chow (D). Transcript expressions of Adgre1 (gene coding for F4/80) (B,E) and Il1b (C,F) in the liver of mice treated according to the protocol depicted in Figure 6E and fed on an HFD (B,C) or chow (E,F). *p < 0.05 versus scrambled (SCh or SCc, scrabbled fed on HFD or chow). ^#p < 0.05 versus overexpression (OEh or OEc, overexpression fed on HFD or chow). KD, Knockdown; KDc, knockdown fed on chow; KDh, knockdown fed on HFD; OE, overexpression; OEc, overexpression fed on chow; OEh, overexpression fed on HFD; SC, scrambled; SCc, scrabbled fed on chow; SCh, scrambles fed on HFD. In all experiments, n = 5-9.