CGRP mAbs block IL-6-induced mechanical hypersensitivity and development of hyperalgesic priming in female mice and rats. A, Mice were given an intraperitoneal injection of 20 mg/kg CGRP mAb, 20 mg/kg control mAb, or vehicle 24 h before receiving an intraplantar injection of 0.1 ng of IL-6. After initial hypersensitivity had resolved, animals received an intraperitoneal injection of either CGRP mAb or control mAb at the doses described above 24 h before a 100 ng PGE₂ intraplantar injection (n = 6 mice/group). Stars show significant differences versus control Ab. B, Rats received an intraperitoneal injection of 20 mg/kg CGRP mAb, 20 mg/kg control mAb, or vehicle 24 h before an intraplantar injection of 0.1 ng of IL-6 or saline, and, once mechanical hypersensitivity had resolved, animals received an intraperitoneal injection of the same drug or vehicle 24 h before intraplantar injection of 100 ng of PGE2 (n = 6 rats/group). Stars show significant differences versus vehicle treatment, color coded by group. Differences between groups were measured using a two-way ANOVA with Bonferroni's post hoc test: *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001.